Picture of smart phone in human hand

World leading smartphone and mobile technology research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by Strathclyde researchers from the Department of Computer & Information Sciences involved in researching exciting new applications for mobile and smartphone technology. But the transformative application of mobile technologies is also the focus of research within disciplines as diverse as Electronic & Electrical Engineering, Marketing, Human Resource Management and Biomedical Enginering, among others.

Explore Strathclyde's Open Access research on smartphone technology now...

Non-invasive analysis in micro-reactors using Raman spectrometry with a specially designed probe

Mozharov, Sergey and Nordon, A. and Girkin, John and Littlejohn, D. (2010) Non-invasive analysis in micro-reactors using Raman spectrometry with a specially designed probe. Lab on a Chip, 10 (16). pp. 2101-2107. ISSN 1473-0197

[img] Microsoft Word (Manuscript_text_figs_final-AN.doc)
Manuscript_text_figs_final-AN.doc - Preprint

Download (457kB)

Abstract

An optical interface has been designed to maximise the sensitivity and spatial resolution required when Raman spectrometry is used to monitor a reaction in a micro-reactor, revealing advantages over a conventional commercial probe. A miniature aspheric lens was shown to be better than microscope objectives to focus the probing laser beam on to the sample. The diameters of the exciting and collection optical fibres were also shown to have a significant influence on sensitivity and the signal to background ratio, with 62.5 m diameter 0.28 numerical aperture (NA) fibres found to be best for analysis of liquids in the 150 m-deep channel in the micro-reactor used. With a spectral measurement time of 2 s, it was shown that the probe could monitor the progress of an esterification reaction in real time and quickly optimise the reagent flow rates. The fast response time revealed features related to short-term pump instabilities and micro-reactor rheology effects that would not have been identified without rapid real-time measurements.