Strathprints logo
Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Blocked dihydropteridines as nitric oxide synthase activators

McInnes, Craig R. and Suckling, C.J. and Gibson, C.L. and Morthala, Raghavendar R. and Daff, Simon and Gazur, Ben (2010) Blocked dihydropteridines as nitric oxide synthase activators. Pteridines, 20. pp. 27-35. ISSN 0933-4807

[img]
Preview
PDF (strathprints027551.pdf)
Download (522Kb) | Preview

    Abstract

    It has been shown that 6-acetyl-7,7-dimethyl-5,6,7,8-tetrahydropteridin-4(3H)-one can act as a competent cofactor for the production of nitric oxide by neuronal nitric oxide synthase (nNOS). More information was sought on the structural features that could contribute to strong binding within the enzyme whilst maintaining a fast electron transfer rate. This study was concerned with expansion at the C2-position of the pteridine scaffold. The evidence suggests that expansion at the C2-position had a deleterious effect with respect to Km and as a consequence electron transfer rate. Unexpectedly, several lines of evidence suggested that a methyl substituent on nitrogen at C2 reduced the electron density in the pyrimidine and dihydropterin rings.

    Item type: Article
    ID code: 27551
    Keywords: dihydropteridines, s nitric oxide, synthase activators, pteridines, Chemistry, Biochemistry, Molecular Medicine, Clinical Biochemistry
    Subjects: Science > Chemistry
    Department: Faculty of Science > Pure and Applied Chemistry
    Related URLs:
    Depositing user: Ms Carol Khalaf
    Date Deposited: 01 Oct 2010 15:50
    Last modified: 06 Sep 2014 00:09
    URI: http://strathprints.strath.ac.uk/id/eprint/27551

    Actions (login required)

    View Item

    Fulltext Downloads: