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Biocatalytic induction of supramolecular order

Hirst, Andrew R. and Roy, Sangita and Arora, Meenakshi and Das, Apurba and Hodson, Nigel and Murray, Paul and Marshall, Stephen and Javid, Nadeem and Sefcik, Jan and Boekhoven, Job and van Esch, Jan H. and Santabarbara, Stefano and Hunt, Neil T. and Ulijn, Rein V. (2010) Biocatalytic induction of supramolecular order. Nature Chemistry, 2 (12). 1089–1094. ISSN 1755-4330

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Abstract

Supramolecular gels, which demonstrate tunable functionalities, have attracted much interest in a range of areas, including healthcare, environmental protection and energy-related technologies. Preparing these materials in a reliable manner is challenging, with an increased level of kinetic defects observed at higher self-assembly rates. Here, by combining biocatalysis and molecular self-assembly, we have shown the ability to more quickly access higher-ordered structures. By simply increasing enzyme concentration, supramolecular order expressed at molecular, nano- and micro-levels is dramatically enhanced, and, importantly, the gelator concentrations remain identical. Amphiphile molecules were prepared by attaching an aromatic moiety to a dipeptide backbone capped with a methyl ester. Their self-assembly was induced by an enzyme that hydrolysed the ester. Different enzyme concentrations altered the catalytic activity and size of the enzyme clusters, affecting their mobility. This allowed structurally diverse materials that represent local minima in the free energy landscape to be accessed based on a single gelator structure.

Item type: Article
ID code: 27078
Keywords: sol-gel transition, peptide nanotubes, enzymatic formation, light-scattering, rational design, self, hydrogels, molecules, gelation, Chemical technology, Chemistry, Chemical Engineering(all), Chemistry(all)
Subjects: Technology > Chemical technology
Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Faculty of Science > Physics
Faculty of Engineering > Electronic and Electrical Engineering
Faculty of Engineering > Chemical and Process Engineering
Related URLs:
Depositing user: Miss Fiona Buggy
Date Deposited: 15 Nov 2010 16:56
Last modified: 28 Mar 2014 05:29
URI: http://strathprints.strath.ac.uk/id/eprint/27078

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