Rolinski, O.J. and Amaro, M. and Birch, D.J.S. (2010) Early detection of amyloid aggregation using intrinsic fluorescence. Biosensors and Bioelectronics, 25 (10). pp. 2249-2252. ISSN 0956-5663
Full text not available in this repository. (Request a copy from the Strathclyde author)Official URL: http://dx.doi.org/10.1016/j.bios.2010.03.005
Abstract
Beta-amyloid (Au) aggregation, believed to be responsible for Alzheimer's disease, is monitored using its intrinsic fluorescence decay. Alterations in the fluorescence decay of tyrosine correlate with the A beta aggregation at a much earlier stage than the traditionally used fluorescence intensity of Thioflavin T (ThT). Potentially the finding may underpin progress towards an earlier diagnosis of the onset of Alzheimer's disease and an improved approach to developing intervention therapies.
| Item type: | Article |
|---|---|
| ID code: | 26575 |
| Keywords: | protein aggregation, fluorescence decay, Beta amyloid (A beta), alzheimer's disease, Tyrosine photophysics, Physics |
| Subjects: | Science > Physics |
| Department: | Faculty of Science > Physics |
| Related URLs: | |
| Depositing user: | Miss Leonie Airley |
| Date Deposited: | 10 Aug 2010 14:14 |
| Last modified: | 23 Aug 2012 16:41 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/26575 |
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