Rolinski, O.J. and Amaro, M. and Birch, D.J.S. (2010) Early detection of amyloid aggregation using intrinsic fluorescence. Biosensors and Bioelectronics, 25 (10). pp. 2249-2252. ISSN 0956-5663Full text not available in this repository. (Request a copy from the Strathclyde author)
Beta-amyloid (Au) aggregation, believed to be responsible for Alzheimer's disease, is monitored using its intrinsic fluorescence decay. Alterations in the fluorescence decay of tyrosine correlate with the A beta aggregation at a much earlier stage than the traditionally used fluorescence intensity of Thioflavin T (ThT). Potentially the finding may underpin progress towards an earlier diagnosis of the onset of Alzheimer's disease and an improved approach to developing intervention therapies.
|Keywords:||protein aggregation, fluorescence decay, Beta amyloid (A beta), alzheimer's disease, Tyrosine photophysics, Physics, Biomedical Engineering, Electrochemistry, Biotechnology, Biophysics|
|Subjects:||Science > Physics|
|Department:||Faculty of Science > Physics|
|Depositing user:||Miss Leonie Airley|
|Date Deposited:||10 Aug 2010 13:14|
|Last modified:||22 Mar 2017 11:11|