Picture of virus under microscope

Research under the microscope...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

Explore SIPBS research

Early detection of amyloid aggregation using intrinsic fluorescence

Rolinski, O.J. and Amaro, M. and Birch, D.J.S. (2010) Early detection of amyloid aggregation using intrinsic fluorescence. Biosensors and Bioelectronics, 25 (10). pp. 2249-2252. ISSN 0956-5663

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Beta-amyloid (Au) aggregation, believed to be responsible for Alzheimer's disease, is monitored using its intrinsic fluorescence decay. Alterations in the fluorescence decay of tyrosine correlate with the A beta aggregation at a much earlier stage than the traditionally used fluorescence intensity of Thioflavin T (ThT). Potentially the finding may underpin progress towards an earlier diagnosis of the onset of Alzheimer's disease and an improved approach to developing intervention therapies.