Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Early detection of amyloid aggregation using intrinsic fluorescence

Rolinski, O.J. and Amaro, M. and Birch, D.J.S. (2010) Early detection of amyloid aggregation using intrinsic fluorescence. Biosensors and Bioelectronics, 25 (10). pp. 2249-2252. ISSN 0956-5663

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Beta-amyloid (Au) aggregation, believed to be responsible for Alzheimer's disease, is monitored using its intrinsic fluorescence decay. Alterations in the fluorescence decay of tyrosine correlate with the A beta aggregation at a much earlier stage than the traditionally used fluorescence intensity of Thioflavin T (ThT). Potentially the finding may underpin progress towards an earlier diagnosis of the onset of Alzheimer's disease and an improved approach to developing intervention therapies.

Item type: Article
ID code: 26575
Keywords: protein aggregation, fluorescence decay, Beta amyloid (A beta), alzheimer's disease, Tyrosine photophysics, Physics, Biomedical Engineering, Electrochemistry, Biotechnology, Biophysics
Subjects: Science > Physics
Department: Faculty of Science > Physics
Related URLs:
    Depositing user: Miss Leonie Airley
    Date Deposited: 10 Aug 2010 14:14
    Last modified: 28 Mar 2014 05:29
    URI: http://strathprints.strath.ac.uk/id/eprint/26575

    Actions (login required)

    View Item