Early detection of amyloid aggregation using intrinsic fluorescence

Rolinski, O.J. and Amaro, M. and Birch, D.J.S. (2010) Early detection of amyloid aggregation using intrinsic fluorescence. Biosensors and Bioelectronics, 25 (10). pp. 2249-2252. ISSN 0956-5663 (https://doi.org/10.1016/j.bios.2010.03.005)

Abstract

Beta-amyloid (Au) aggregation, believed to be responsible for Alzheimer's disease, is monitored using its intrinsic fluorescence decay. Alterations in the fluorescence decay of tyrosine correlate with the A beta aggregation at a much earlier stage than the traditionally used fluorescence intensity of Thioflavin T (ThT). Potentially the finding may underpin progress towards an earlier diagnosis of the onset of Alzheimer's disease and an improved approach to developing intervention therapies.

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• Item metadata

  Item type:	Article
  ID code:	26575
  Dates:	Date Event 15 June 2010 Published
  Subjects:	Science > Physics
  Department:	Faculty of Science > Physics
  Depositing user:	Users 1261 not found.
  Date deposited:	10 Aug 2010 13:14
  Last modified:	08 Apr 2024 18:40
  URI:	https://strathprints.strath.ac.uk/id/eprint/26575