Picture of two heads

Open Access research that challenges the mind...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

Discover more...

Early detection of amyloid aggregation using intrinsic fluorescence

Rolinski, O.J. and Amaro, M. and Birch, D.J.S. (2010) Early detection of amyloid aggregation using intrinsic fluorescence. Biosensors and Bioelectronics, 25 (10). pp. 2249-2252. ISSN 0956-5663

Full text not available in this repository. (Request a copy from the Strathclyde author)


Beta-amyloid (Au) aggregation, believed to be responsible for Alzheimer's disease, is monitored using its intrinsic fluorescence decay. Alterations in the fluorescence decay of tyrosine correlate with the A beta aggregation at a much earlier stage than the traditionally used fluorescence intensity of Thioflavin T (ThT). Potentially the finding may underpin progress towards an earlier diagnosis of the onset of Alzheimer's disease and an improved approach to developing intervention therapies.