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Early detection of amyloid aggregation using intrinsic fluorescence

Rolinski, O.J. and Amaro, M. and Birch, D.J.S. (2010) Early detection of amyloid aggregation using intrinsic fluorescence. Biosensors and Bioelectronics, 25 (10). pp. 2249-2252. ISSN 0956-5663

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Beta-amyloid (Au) aggregation, believed to be responsible for Alzheimer's disease, is monitored using its intrinsic fluorescence decay. Alterations in the fluorescence decay of tyrosine correlate with the A beta aggregation at a much earlier stage than the traditionally used fluorescence intensity of Thioflavin T (ThT). Potentially the finding may underpin progress towards an earlier diagnosis of the onset of Alzheimer's disease and an improved approach to developing intervention therapies.

Item type: Article
ID code: 26575
Keywords: protein aggregation, fluorescence decay, Beta amyloid (A beta), alzheimer's disease, Tyrosine photophysics, Physics, Biomedical Engineering, Electrochemistry, Biotechnology, Biophysics
Subjects: Science > Physics
Department: Faculty of Science > Physics
Depositing user: Miss Leonie Airley
Date Deposited: 10 Aug 2010 13:14
Last modified: 04 Sep 2015 04:05

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