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A two-layer diffusive model for describing the variability of transdermal drug permeation

Meidan, V.M. and Pritchard, D. (2010) A two-layer diffusive model for describing the variability of transdermal drug permeation. European Journal of Pharmaceutics and Biopharmaceutics, 74 (3). pp. 513-517. ISSN 0939-6411

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Abstract

There is mounting evidence that the permeability coefficients (kp) that describe any given transdermal drug permeation process generally follow some form of positively skewed, non-symmetrical distribution rather than a simple normal distribution. Yet a suitable theoretical treatment of this area has not been undertaken to date. In this paper, we describe a two-layer model that can explain five drugs' kp variabilities as measured in two previously published papers. The model shows why rapidly permeating drugs would tend to exhibit more symmetrical kp distributions while progressively more slowly permeating drugs would tend to exhibit progressively more positively skewed kp distributions. Future research should take this effect into account when comparing the flux variabilities of hydrophilic and lipophilic drugs.

Item type: Article
ID code: 26160
Keywords: transdermal , flux, permeation, variability, skewness, two-layer model, Therapeutics. Pharmacology, Pharmaceutical Science, Biotechnology
Subjects: Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Mathematics and Statistics
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Depositing user: Strathprints Administrator
Date Deposited: 18 Apr 2011 11:12
Last modified: 27 Mar 2014 08:57
URI: http://strathprints.strath.ac.uk/id/eprint/26160

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