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Xanalteric acid I and II and the related phenolic compounds from endophytic Alternaria sp. isolated from mangrove plant Sonneratia alba

Kjer, J. and Wray, V. and Edrada-Ebel, R.A. and Ebel, R. and Pretsch, A. and Lin, W.H. and Proksch, P. (2009) Xanalteric acid I and II and the related phenolic compounds from endophytic Alternaria sp. isolated from mangrove plant Sonneratia alba. Journal of Natural Products, 72 (11). pp. 2053-2057. ISSN 0163-3864

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Abstract

Two new 10-oxo-10H-phenaleno[1,2,3-de]chromene-2-carboxylic acids, xanalteric acids I (1) and II (2), and 11 known secondary metabolites were obtained from extracts of the endophytic fungus Alternaria sp., isolated from the mangrove plant Sonneratia alba collected in China. The metabolites were confirmed to be of fungal origin, and the structures of the new natural products were unambiguously elucidated on the basis of extensive one- and two-dimensional NMR spectroscopic studies and mass spectrometric analysis. The two new compounds 1 and 2 exhibited weak antibiotic activity against multidrug-resistant Staphylococcus aureus. Altenusin (3) displayed broad antimicrobial activity against several additional multidrug-resistant bacterial and fungal strains.