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Xanalteric acid I and II and the related phenolic compounds from endophytic Alternaria sp. isolated from mangrove plant Sonneratia alba

Kjer, J. and Wray, V. and Edrada-Ebel, R.A. and Ebel, R. and Pretsch, A. and Lin, W.H. and Proksch, P. (2009) Xanalteric acid I and II and the related phenolic compounds from endophytic Alternaria sp. isolated from mangrove plant Sonneratia alba. Journal of Natural Products, 72 (11). pp. 2053-2057. ISSN 0163-3864

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Abstract

Two new 10-oxo-10H-phenaleno[1,2,3-de]chromene-2-carboxylic acids, xanalteric acids I (1) and II (2), and 11 known secondary metabolites were obtained from extracts of the endophytic fungus Alternaria sp., isolated from the mangrove plant Sonneratia alba collected in China. The metabolites were confirmed to be of fungal origin, and the structures of the new natural products were unambiguously elucidated on the basis of extensive one- and two-dimensional NMR spectroscopic studies and mass spectrometric analysis. The two new compounds 1 and 2 exhibited weak antibiotic activity against multidrug-resistant Staphylococcus aureus. Altenusin (3) displayed broad antimicrobial activity against several additional multidrug-resistant bacterial and fungal strains.

Item type: Article
ID code: 26137
Keywords: xanalteric acid, phenolic compounds, endophytic alternaria, mangrove plants, pharmacology, Pharmacy and materia medica, Microbiology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
Subjects: Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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    Depositing user: Strathprints Administrator
    Date Deposited: 25 Aug 2010 15:28
    Last modified: 05 Sep 2014 05:17
    URI: http://strathprints.strath.ac.uk/id/eprint/26137

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