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The potential of metabolomics for Leishmania research in the post-genomics era

Scheltema, Richard A. and Decuypere, Saskia and T'Kindt, Ruben and Dujardin, Jean-Claude and Coombs, Graham H. and Breitling, Rainer (2010) The potential of metabolomics for Leishmania research in the post-genomics era. Parasitology, 137 (9). pp. 1291-1302. ISSN 0031-1820

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Abstract

The post-genomics era has provided researchers with access to a new generation of tools for the global characterization and understanding of pathogen diversity. This review provides a critical summary of published Leishmania post-genomic research efforts to date, and discusses the potential impact of the addition of metabolomics to the post-genomic toolbox. Metabolomics aims at understanding biology by comprehensive metabolite profiling. We present an overview of the design and interpretation of metabolomics experiments in the context of Leishmania research. Sample preparation, measurement techniques, and bioinformatics analysis of the generated complex datasets are discussed in detail. To illustrate the concepts and the expected results of metabolomics analyses, we also present an overview of comparative metabolic profiles of drug-sensitive and drug-resistant Leishmania donovani clinical isolates.

Item type: Article
ID code: 26121
Keywords: Post-genomics research, metabolomics, mass spectrometry, liquid chromatography, Leishmania, protozoan parasite leishmania, differential gene-expression, transform mass-spectrometry, resistant leishmania, intracellular metabolites, sequencing technologies, systems biology, donovani, reveals, modulation, Pharmacy and materia medica, Infectious Diseases, Animal Science and Zoology, Parasitology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Strathprints Administrator
Date Deposited: 20 Sep 2010 14:06
Last modified: 14 Nov 2014 05:02
URI: http://strathprints.strath.ac.uk/id/eprint/26121

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