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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Drug target identification, validation, characterisation and exploitation for treatment of Acanthamoeba (species) infections

Roberts, Craig W. and Henriquez, Fiona L. (2010) Drug target identification, validation, characterisation and exploitation for treatment of Acanthamoeba (species) infections. Experimental Parasitology, 126 (1). pp. 91-96. ISSN 0014-4894

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Abstract

New more efficacious antimicrobials as required for the treatment of Acanthamoeba infections as those currently available require arduous treatment regimes, are not always effective and are poorly active against the cystic stages. Herein, we review potential drug targets including tubulin, alternative oxidase, amino acid biosynthesis and myosin. In addition, we review the literature for current missing tools and resources for the identification, validation and development of new antimicrobials for this organism. Additional targets should come to light through a concerted genome sequencing effort.