Picture of virus under microscope

Research under the microscope...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

Explore SIPBS research

Drug target identification, validation, characterisation and exploitation for treatment of Acanthamoeba (species) infections

Roberts, Craig W. and Henriquez, Fiona L. (2010) Drug target identification, validation, characterisation and exploitation for treatment of Acanthamoeba (species) infections. Experimental Parasitology, 126 (1). pp. 91-96. ISSN 0014-4894

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

New more efficacious antimicrobials as required for the treatment of Acanthamoeba infections as those currently available require arduous treatment regimes, are not always effective and are poorly active against the cystic stages. Herein, we review potential drug targets including tubulin, alternative oxidase, amino acid biosynthesis and myosin. In addition, we review the literature for current missing tools and resources for the identification, validation and development of new antimicrobials for this organism. Additional targets should come to light through a concerted genome sequencing effort.