Roberts, Craig W. and Henriquez, Fiona L. (2010) Drug target identification, validation, characterisation and exploitation for treatment of Acanthamoeba (species) infections. Experimental Parasitology, 126 (1). pp. 91-96. ISSN 0014-4894
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
New more efficacious antimicrobials as required for the treatment of Acanthamoeba infections as those currently available require arduous treatment regimes, are not always effective and are poorly active against the cystic stages. Herein, we review potential drug targets including tubulin, alternative oxidase, amino acid biosynthesis and myosin. In addition, we review the literature for current missing tools and resources for the identification, validation and development of new antimicrobials for this organism. Additional targets should come to light through a concerted genome sequencing effort.
| Item type: | Article |
|---|---|
| ID code: | 26112 |
| Keywords: | Acanthamoeba, drug targets, drug validation, antimicrobials, tubulin, alternative oxidase, amino acid biosynthesis, myosin, Therapeutics. Pharmacology, Microbiology |
| Subjects: | Medicine > Therapeutics. Pharmacology Science > Microbiology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Strathprints Administrator |
| Date Deposited: | 21 Sep 2010 14:55 |
| Last modified: | 04 Oct 2012 13:30 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/26112 |
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