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Drug target identification, validation, characterisation and exploitation for treatment of Acanthamoeba (species) infections

Roberts, Craig W. and Henriquez, Fiona L. (2010) Drug target identification, validation, characterisation and exploitation for treatment of Acanthamoeba (species) infections. Experimental Parasitology, 126 (1). pp. 91-96. ISSN 0014-4894

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Abstract

New more efficacious antimicrobials as required for the treatment of Acanthamoeba infections as those currently available require arduous treatment regimes, are not always effective and are poorly active against the cystic stages. Herein, we review potential drug targets including tubulin, alternative oxidase, amino acid biosynthesis and myosin. In addition, we review the literature for current missing tools and resources for the identification, validation and development of new antimicrobials for this organism. Additional targets should come to light through a concerted genome sequencing effort.

Item type: Article
ID code: 26112
Notes: Special Issue - Biology and Pathogenecity of Free-Living Amoebae. Compiled after the XIIIth International Meeting on the Biology and Pathogenicity of Free-Living Amoebae, FLAM 2009, Tenerife, Spain
Keywords: acanthamoeba, drug targets, drug validation, antimicrobials, tubulin, alternative oxidase, amino acid biosynthesis, myosin, Therapeutics. Pharmacology, Microbiology, Immunology, Parasitology, Pharmacology, Toxicology and Pharmaceutics(all)
Subjects: Medicine > Therapeutics. Pharmacology
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Strathprints Administrator
Date Deposited: 21 Sep 2010 14:55
Last modified: 04 Apr 2014 12:34
URI: http://strathprints.strath.ac.uk/id/eprint/26112

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