Picture of a black hole

Strathclyde Open Access research that creates ripples...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of research papers by University of Strathclyde researchers, including by Strathclyde physicists involved in observing gravitational waves and black hole mergers as part of the Laser Interferometer Gravitational-Wave Observatory (LIGO) - but also other internationally significant research from the Department of Physics. Discover why Strathclyde's physics research is making ripples...

Strathprints also exposes world leading research from the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

Discover more...

Differential regulation of protein subdomain activity with caged bivalent ligands

Mayer, G. and Müller, J. and Mack, T. and Freitag, D.F. and Höver, T. and Pötzsch, Bernd and Heckel, A. (2009) Differential regulation of protein subdomain activity with caged bivalent ligands. Chembiochem, 10 (4). pp. 654-657. ISSN 1439-4227

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Spatiotemporal modulation of individual protein subdomains with light as the trigger signal becomes possible by using bivalent aptamers and introducing photolabile 'caging groups' to switch individual aptamer modules ON or OFF differentially. To the best of our knowledge, this is the first study to show that it is possible to modulate individual domain activity in aptamers, and thus also domain activity in proteins, with light.