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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.

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Differential regulation of protein subdomain activity with caged bivalent ligands

Mayer, G. and Müller, J. and Mack, T. and Freitag, D.F. and Höver, T. and Pötzsch, Bernd and Heckel, A. (2009) Differential regulation of protein subdomain activity with caged bivalent ligands. Chembiochem, 10 (4). pp. 654-657. ISSN 1439-4227

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Abstract

Spatiotemporal modulation of individual protein subdomains with light as the trigger signal becomes possible by using bivalent aptamers and introducing photolabile 'caging groups' to switch individual aptamer modules ON or OFF differentially. To the best of our knowledge, this is the first study to show that it is possible to modulate individual domain activity in aptamers, and thus also domain activity in proteins, with light.