Mayer, G. and Müller, J. and Mack, T. and Freitag, D.F. and Höver, T. and Pötzsch, Bernd and Heckel, A. (2009) Differential regulation of protein subdomain activity with caged bivalent ligands. Chembiochem, 10 (4). pp. 654-657. ISSN 1439-4227
Full text not available in this repository. (Request a copy from the Strathclyde author)Official URL: http://dx.doi.org/10.1002/cbic.200800814
Abstract
Spatiotemporal modulation of individual protein subdomains with light as the trigger signal becomes possible by using bivalent aptamers and introducing photolabile 'caging groups' to switch individual aptamer modules ON or OFF differentially. To the best of our knowledge, this is the first study to show that it is possible to modulate individual domain activity in aptamers, and thus also domain activity in proteins, with light.
| Item type: | Article |
|---|---|
| ID code: | 26090 |
| Keywords: | aptamers, blood clotting, caged compounds, dna, molecular switches, Therapeutics. Pharmacology |
| Subjects: | Medicine > Therapeutics. Pharmacology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Strathprints Administrator |
| Date Deposited: | 31 Aug 2010 16:34 |
| Last modified: | 12 Mar 2012 11:16 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/26090 |
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