Mayer, G. and Müller, J. and Mack, T. and Freitag, D.F. and Höver, T. and Pötzsch, Bernd and Heckel, A. (2009) Differential regulation of protein subdomain activity with caged bivalent ligands. Chembiochem, 10 (4). pp. 654-657. ISSN 1439-4227Full text not available in this repository. (Request a copy from the Strathclyde author)
Spatiotemporal modulation of individual protein subdomains with light as the trigger signal becomes possible by using bivalent aptamers and introducing photolabile 'caging groups' to switch individual aptamer modules ON or OFF differentially. To the best of our knowledge, this is the first study to show that it is possible to modulate individual domain activity in aptamers, and thus also domain activity in proteins, with light.
|Keywords:||aptamers, blood clotting, caged compounds, dna, molecular switches, Therapeutics. Pharmacology, Medicine(all)|
|Subjects:||Medicine > Therapeutics. Pharmacology|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Strathprints Administrator|
|Date Deposited:||31 Aug 2010 15:34|
|Last modified:||21 Apr 2017 05:09|