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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Differential regulation of protein subdomain activity with caged bivalent ligands

Mayer, G. and Müller, J. and Mack, T. and Freitag, D.F. and Höver, T. and Pötzsch, Bernd and Heckel, A. (2009) Differential regulation of protein subdomain activity with caged bivalent ligands. Chembiochem, 10 (4). pp. 654-657. ISSN 1439-4227

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Abstract

Spatiotemporal modulation of individual protein subdomains with light as the trigger signal becomes possible by using bivalent aptamers and introducing photolabile 'caging groups' to switch individual aptamer modules ON or OFF differentially. To the best of our knowledge, this is the first study to show that it is possible to modulate individual domain activity in aptamers, and thus also domain activity in proteins, with light.