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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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A RNA-based approach towards small molecule inhibitors

Mayer, G. and Faulhammer, D. and Grättinger, M. and Fessele, S. and Blind, M. (2009) A RNA-based approach towards small molecule inhibitors. Chembiochem, 10 (12). pp. 1993-1996. ISSN 1439-4227

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Abstract

The identification of low-molecular-weight protein inhibitors for functional studies as well as for the generation of lead drug compounds is one of the most important tasks in chemical biology. We describe a generalized assay that utilizes inhibitory aptamers for the identification of small molecules with aptamer-inherited properties. These compounds share the functional profile of the aptamers and thus are considered as potent protein inhibitors.