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A RNA-based approach towards small molecule inhibitors

Mayer, G. and Faulhammer, D. and Grättinger, M. and Fessele, S. and Blind, M. (2009) A RNA-based approach towards small molecule inhibitors. Chembiochem, 10 (12). pp. 1993-1996. ISSN 1439-4227

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The identification of low-molecular-weight protein inhibitors for functional studies as well as for the generation of lead drug compounds is one of the most important tasks in chemical biology. We describe a generalized assay that utilizes inhibitory aptamers for the identification of small molecules with aptamer-inherited properties. These compounds share the functional profile of the aptamers and thus are considered as potent protein inhibitors.

Item type: Article
ID code: 26087
Keywords: aptamers, high-throughput screening, protein inhibitors, RiboGreen, SELEX, Chemistry, Genetics, Biology, Pharmacy and materia medica, Medicine(all)
Subjects: Science > Chemistry
Science > Natural history > Genetics
Science > Natural history > Biology
Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Strathprints Administrator
Date Deposited: 03 Sep 2010 13:41
Last modified: 21 May 2015 12:28

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