A RNA-based approach towards small molecule inhibitors

Mayer, G. and Faulhammer, D. and Grättinger, M. and Fessele, S. and Blind, M. (2009) A RNA-based approach towards small molecule inhibitors. Chembiochem, 10 (12). pp. 1993-1996. ISSN 1439-4227 (http://dx.doi.org/10.1002/cbic.200900325)

Abstract

The identification of low-molecular-weight protein inhibitors for functional studies as well as for the generation of lead drug compounds is one of the most important tasks in chemical biology. We describe a generalized assay that utilizes inhibitory aptamers for the identification of small molecules with aptamer-inherited properties. These compounds share the functional profile of the aptamers and thus are considered as potent protein inhibitors.

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• Item metadata

  Item type:	Article
  ID code:	26087
  Dates:	Date Event 2009 Published
  Subjects:	Science > Chemistry Science > Natural history > Genetics Science > Natural history > Biology Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Strathprints Administrator
  Date deposited:	03 Sep 2010 13:41
  Last modified:	08 Apr 2024 18:20
  URI:	https://strathprints.strath.ac.uk/id/eprint/26087