Mayer, G. and Faulhammer, D. and Grättinger, M. and Fessele, S. and Blind, M. (2009) A RNA-based approach towards small molecule inhibitors. Chembiochem, 10 (12). pp. 1993-1996. ISSN 1439-4227
Full text not available in this repository. (Request a copy from the Strathclyde author)Official URL: http://dx.doi.org/10.1002/cbic.200900325
Abstract
The identification of low-molecular-weight protein inhibitors for functional studies as well as for the generation of lead drug compounds is one of the most important tasks in chemical biology. We describe a generalized assay that utilizes inhibitory aptamers for the identification of small molecules with aptamer-inherited properties. These compounds share the functional profile of the aptamers and thus are considered as potent protein inhibitors.
| Item type: | Article |
|---|---|
| ID code: | 26087 |
| Keywords: | aptamers, high-throughput screening, protein inhibitors, RiboGreen, SELEX, Chemistry, Genetics, Biology, Pharmacy and materia medica |
| Subjects: | Science > Chemistry Science > Natural history > Genetics Science > Natural history > Biology Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Strathprints Administrator |
| Date Deposited: | 03 Sep 2010 14:41 |
| Last modified: | 12 Mar 2012 11:16 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/26087 |
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