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Mast cells, peptides and cardioprotection - An unlikely marriage?

Walsh, S.K. and Kane, K.A. and Wainwright, C.L. (2009) Mast cells, peptides and cardioprotection - An unlikely marriage? Autonomic and Autacoid Pharmacology, 29 (3). pp. 73-84. ISSN 1474-8665

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Abstract

Mast cells have classically been regarded as the 'bad guys' in the setting of acute myocardial ischaemia, where their released contents are believed to contribute both to tissue injury and electrical disturbances resulting from ischaemia. Recent evidence suggests, however, that if mast cell degranulation occurs in advance of ischaemia onset, this may be cardioprotective by virtue of the depletion of mast cell contents that can no longer act as instruments of injury when the tissue becomes ischaemic. Many peptides, such as ET-1, adrenomedullin, relaxin and atrial natriuretic peptide, have been demonstrated to be cardioprotective when given prior to the onset of myocardial ischaemia, although their physiological functions are varied and the mechanisms of their cardioprotective actions appear to be diverse and often ill defined. However, one common denominator that is emerging is the ability of these peptides to modulate mast cell degranulation, raising the possibility that peptide-induced mast cell degranulation or stabilization may hold the key to a common mechanism of their cardioprotection. The aim of this review was to consolidate the evidence implying that mast cell degranulation could play both a detrimental and protective role in myocardial ischaemia, depending upon when it occurs, and that this may underlie the cardioprotective effects of a range of diverse peptides that exerts physiological effects within the cardiovascular system.

Item type: Article
ID code: 26063
Keywords: myocardial ischaemia, cardioprotection, mast cells, endothelin, adrenomedullin, relaxin, atrial natriuretic peptide, Internal medicine
Subjects: Medicine > Internal medicine
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Physiology and Pharmacology
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    Depositing user: Strathprints Administrator
    Date Deposited: 08 Sep 2010 12:20
    Last modified: 17 Jul 2013 02:03
    URI: http://strathprints.strath.ac.uk/id/eprint/26063

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