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Adjuvants : an essential component of neisseria vaccines

Acevedo, R. and Romeu, B. and del Campo, J. and Gonzales, E. and Balbao, J. and Zayas, C. and Cuello, M. and Cabrera, O. and Ferro, Valerie A. (2009) Adjuvants : an essential component of neisseria vaccines. VacciMonitor, 18 (2). pp. 93-96. ISSN 1025-028X

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    Abstract

    Adjuvants may be classified into delivery systems and immune potentiator or modulator molecules based on their mechanism of action. Neisseria vaccines containing traditional adjuvants such as aluminium salts have existed for long time, but meningitis caused by Neisseria meningitidis serogroups, particularly serogroup B, continues to be a global health problem. Novel strategies have applied in silico and recombinant technologies to develop "universal" antigens (e.g. proteins, peptides and plasmid DNA) for vaccines, but these antigens have been shown to be poorly immunogenic even when alum adjuvanted, implying a need for better vaccine design. In this work we review the use of natural, detoxified, or synthetic molecules in combination with antigens to activate the innate immune system and to modulate the adaptive immune responses. In the main, antigenic and imune potentiator signals are delivered using nano-, micro-particles, alum, or emulsions. The importance of interaction between adjuvants and antigens to activate and target dendritic cells, the bridge between the innate and adaptive immune systems, will be discussed. In addition, nasal vaccine strategies based on the development of mucosal adjuvants and Neisseria derivatives to eliminate the pathogen at the site of infection provide promising adjuvants effective not only against respiratory pathogens, but also against pathogens responsible for enteric and sexually transmitted diseases.

    Item type: Article
    ID code: 26058
    Notes: Strathprints' policy is to record up to 8 authors per publication, plus any additional authors based at the University of Strathclyde. More authors may be listed on the official publication than appear in the Strathprints' record.
    Keywords: adjuvant, micro-particle, nano-particle, neisseria, vaccine, delivery system, immune potentiator, Therapeutics. Pharmacology, Molecular Medicine, Drug Discovery, Immunology, Immunology and Allergy
    Subjects: Medicine > Therapeutics. Pharmacology
    Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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    Depositing user: Strathprints Administrator
    Date Deposited: 19 Aug 2010 12:31
    Last modified: 05 Sep 2014 23:24
    URI: http://strathprints.strath.ac.uk/id/eprint/26058

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