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Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Use of slow release starch (SRS) to treat hypoglycaemia in type 1 diabetics

Qi, E. and Band, M. and Tester, R.F. and Piggott, J.R. and Hurel, S. (2010) Use of slow release starch (SRS) to treat hypoglycaemia in type 1 diabetics. Nutrition and Food Science, 40 (2). pp. 228-234. ISSN 0034-6659

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Abstract

The purpose of this paper is to evaluate if slow release starch (SRS) could be used to control/limit hypoglycaemia in type 1 diabetics. Ten type-1 diabetic volunteers were fitted with continuous glucose monitors for two periods of 3 days when undertaking their normal routine or when consuming 60?g SRS before sleep. The average number of nocturnal hypoglycaemic episodes where no SRS was consumed over 3 days was 2.7?±?2.0 but only 0.7?±?1.1 after SRS consumption before sleep. The duration of these events was equivalent to 318?±?282 and 140?±?337?min, respectively. Average nocturnal blood glucose concentration was 7.9?±?1.4?mmol?l-1 without SRS consumption but increased to 9.7?±?2.7?mmol?l-1 when SRS was consumed. These data were highly significant when subjected to analysis of variance (ANOVA) test on a subject by subject basis. The SRS may be used as a cost effective therapy to avoid hypoglycaemia in patients with type-1 diabetes. This paper reports for the first time the use of a physically modified waxy maize starch (SRS) to prevent/limit the incidence of nocturnal hypoglycaemia in type 1 diabetics.