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Putting pressure on elusive polymorphs and solvates

Oswald, I.D.H. and Chataigner, I. and Elphick, S. and Fabbiani, F.P.A. and Lennie, Alistair R. and Maddaluno, J. and Marshall, William G. and Prior, T.J. and Pulham, Colin R. and Smith, Ronald I. (2009) Putting pressure on elusive polymorphs and solvates. CrystEngComm, 11 (2). pp. 359-366. ISSN 1466-8033

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Abstract

The reproducible crystallisation of elusive polymorphs and solvates of molecular compounds at high pressure has been demonstrated through studies on maleic acid, malonamide, and paracetamol. These high-pressure methods can be scaled-up to produce bulk quantities of metastable forms that can be recovered to ambient pressure for subsequent seeding experiments. This has been demonstrated for paracetamol form II and paracetamol monohydrate. The studies also show that the particular solid form can be tuned by both pressure and concentration.

Item type: Article
ID code: 26040
Keywords: crystallisation, polymorphs, solvates, molecular compounds, high pressure, metastable form, Chemistry, Pharmacy and materia medica, Materials Science(all), Chemistry(all), Condensed Matter Physics
Subjects: Science > Chemistry
Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Professional Services > Information Services
Depositing user: Strathprints Administrator
Date Deposited: 06 Sep 2010 11:51
Last modified: 17 Jun 2015 22:33
URI: http://strathprints.strath.ac.uk/id/eprint/26040

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