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Bioactive secondary metabolites from the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco

Debbab, Adbessamad and Aly, Amal H. and Edrada-Ebel, RuAngelie and Mueller, W.E.G. and Mosaddak, Mahjouba and Hakikj, Adbelhak and Ebel, R. and Proksch, Peter (2009) Bioactive secondary metabolites from the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco. Biotechnology, Agronomy, Society and Environment (BASE), 13 (2). pp. 229-234. ISSN 1370-6233

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Abstract

This study reports the chemical investigation and cytotoxic activity of the secondary metabolites produced by the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco. This plant was collected from the Beni-Mellal Mountain in Morocco and belongs to the Lamiaceae family and is named in Morocco 'Salmia'. The endophytic fungus Chaetomium sp. was isolated from the tissues of the stem of this plant. The fungal strain was identified by PCR. The crude organic extract of the fungal strain was proven to be active when tested for cytotoxicity against L5178Y mouse lymphoma cells. Chemical investigation of the secondary metabolites showed that cochliodinol is the main component beside isocochliodinol. The structures of the isolated compounds were determined on the basis of NMR analysis (1H, 13C, COSY and HMBC) as well as by mass spectrometry using ESI (Electron Spray Ionisation) as source.

Item type: Article
ID code: 26015
Notes: Strathprints' policy is to record up to 8 authors per publication, plus any additional authors based at the University of Strathclyde. More authors may be listed on the official publication than appear in the Strathprints' record.
Keywords: salvia officinalis, endophytic fungi, chaetomium, secondary metabolites, cochliodinol, spectroscopy, cytotoxicity, morocco, Chemistry, Therapeutics. Pharmacology, Biotechnology, Agronomy and Crop Science, Forestry, Geography, Planning and Development, Plant Science
Subjects: Science > Chemistry
Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Strathprints Administrator
Date Deposited: 23 Aug 2010 13:41
Last modified: 24 Jul 2015 06:10
Related URLs:
URI: http://strathprints.strath.ac.uk/id/eprint/26015

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