Strathprints logo
Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Cyclic AMP signalling in pancreatic islets

Furman, Brian L. and Ong, W.K. and Pyne, Nigel J. (2010) Cyclic AMP signalling in pancreatic islets. Advances in Experimental Medicine and Biology, 654. pp. 281-304. ISSN 0065-2598

[img] PDF
AdvexpmedFinal_proof_chapter_13_2_.pdf - Submitted Version

Download (337kB)

Abstract

Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (GLP-1 and GIP). cAMP is rapidly degraded in the pancreatic islet β-cell by various cyclic nucleotide phosphodiesterase (PDE) enzymes. Many steps involved in glucose-induced insulin secretion are modulated by cAMP, which is also important in regulating pancreatic islet β-cell differentiation, growth and survival. This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the β-cell.

Item type: Article
ID code: 25943
Keywords: cyclic amp, adenylyl cyclase, phosphodiesterase, insulin secretion, protein kinase, pancreas, Chemistry, Therapeutics. Pharmacology, Biochemistry, Genetics and Molecular Biology(all), Medicine(all)
Subjects: Science > Chemistry
Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Strathprints Administrator
Date Deposited: 24 Aug 2010 11:24
Last modified: 21 May 2015 12:37
Related URLs:
URI: http://strathprints.strath.ac.uk/id/eprint/25943

Actions (login required)

View Item View Item