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Cyclic AMP signalling in pancreatic islets

Furman, Brian L. and Ong, W.K. and Pyne, Nigel J. (2010) Cyclic AMP signalling in pancreatic islets. Advances in Experimental Medicine and Biology, 654. pp. 281-304. ISSN 0065-2598

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Abstract

Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (GLP-1 and GIP). cAMP is rapidly degraded in the pancreatic islet β-cell by various cyclic nucleotide phosphodiesterase (PDE) enzymes. Many steps involved in glucose-induced insulin secretion are modulated by cAMP, which is also important in regulating pancreatic islet β-cell differentiation, growth and survival. This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the β-cell.