Furman, Brian L. and Ong, W.K. and Pyne, Nigel J. (2010) Cyclic AMP signalling in pancreatic islets. Advances in Experimental Medicine and Biology, 654. pp. 281-304. ISSN 0065-2598
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Abstract
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (GLP-1 and GIP). cAMP is rapidly degraded in the pancreatic islet β-cell by various cyclic nucleotide phosphodiesterase (PDE) enzymes. Many steps involved in glucose-induced insulin secretion are modulated by cAMP, which is also important in regulating pancreatic islet β-cell differentiation, growth and survival. This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the β-cell.
| Item type: | Article |
|---|---|
| ID code: | 25943 |
| Keywords: | cyclic amp, adenylyl cyclase, phosphodiesterase, insulin secretion, protein kinase, pancreas, Chemistry, Therapeutics. Pharmacology |
| Subjects: | Science > Chemistry Medicine > Therapeutics. Pharmacology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Strathprints Administrator |
| Date Deposited: | 24 Aug 2010 12:24 |
| Last modified: | 06 Oct 2012 08:50 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/25943 |
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