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Cyclic AMP signalling in pancreatic islets

Furman, Brian L. and Ong, W.K. and Pyne, Nigel J. (2010) Cyclic AMP signalling in pancreatic islets. Advances in Experimental Medicine and Biology, 654. pp. 281-304. ISSN 0065-2598

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    Abstract

    Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (GLP-1 and GIP). cAMP is rapidly degraded in the pancreatic islet β-cell by various cyclic nucleotide phosphodiesterase (PDE) enzymes. Many steps involved in glucose-induced insulin secretion are modulated by cAMP, which is also important in regulating pancreatic islet β-cell differentiation, growth and survival. This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the β-cell.

    Item type: Article
    ID code: 25943
    Keywords: cyclic amp, adenylyl cyclase, phosphodiesterase, insulin secretion, protein kinase, pancreas, Chemistry, Therapeutics. Pharmacology, Biochemistry, Genetics and Molecular Biology(all), Medicine(all)
    Subjects: Science > Chemistry
    Medicine > Therapeutics. Pharmacology
    Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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    Depositing user: Strathprints Administrator
    Date Deposited: 24 Aug 2010 12:24
    Last modified: 26 Oct 2014 16:12
    URI: http://strathprints.strath.ac.uk/id/eprint/25943

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