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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Applications of mass spectrometry in metabolomic studies of animal model and invertebrate systems

Kamleh, M.A. and Dow, J.A.T. and Watson, D.G. (2009) Applications of mass spectrometry in metabolomic studies of animal model and invertebrate systems. Briefings in Functional Genomics and Proteomics, 8 (1). pp. 28-48. ISSN 1473-9550

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Abstract

Metabolomics provides rich datasets for systems biology. Mass spectrometric (MS) techniques are rapidly gaining in importance for untargeted metabolic profiling. In this review, we survey the various techniques for sample preparation and analysis relating to the various MS techniques and illustrate the potential of these techniques for both observing complete metabolomes and detecting changes in the metabolism resulting from genetic mutation of other perturbations. The use of some of these techniques in the study of model organisms including rodent and various invertebrate models is described. The invertebrate systems are of particular interest since such organisms have valuable mutant resources, such as RNAi panels directed against nearly all the genes in the genome. The demonstration that they are readily compatible with metabolomic approaches is particularly important for systems approaches to metabolic pathways.