Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Applications of mass spectrometry in metabolomic studies of animal model and invertebrate systems

Kamleh, M.A. and Dow, J.A.T. and Watson, D.G. (2009) Applications of mass spectrometry in metabolomic studies of animal model and invertebrate systems. Briefings in Functional Genomics and Proteomics, 8 (1). pp. 28-48. ISSN 1473-9550

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Metabolomics provides rich datasets for systems biology. Mass spectrometric (MS) techniques are rapidly gaining in importance for untargeted metabolic profiling. In this review, we survey the various techniques for sample preparation and analysis relating to the various MS techniques and illustrate the potential of these techniques for both observing complete metabolomes and detecting changes in the metabolism resulting from genetic mutation of other perturbations. The use of some of these techniques in the study of model organisms including rodent and various invertebrate models is described. The invertebrate systems are of particular interest since such organisms have valuable mutant resources, such as RNAi panels directed against nearly all the genes in the genome. The demonstration that they are readily compatible with metabolomic approaches is particularly important for systems approaches to metabolic pathways.

Item type: Article
ID code: 25928
Keywords: animal models, invertebrates, mass spectrometry, metabolomics, systems biology, Therapeutics. Pharmacology, Microbiology, Medicine(all)
Subjects: Medicine > Therapeutics. Pharmacology
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 27 Aug 2010 13:28
    Last modified: 05 Sep 2014 05:17
    URI: http://strathprints.strath.ac.uk/id/eprint/25928

    Actions (login required)

    View Item