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Open Access research that challenges the mind...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

Purcell, Shaun M and Wray, Naomi R and Stone, Jennifer L and Visscher, Peter M and O'Donovan, Michael C and Sullivan, Patrick F and Sklar, Pamela and , International Schizophrenia Consortium and Pickard, Ben (2009) Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature, 460 (7256). pp. 748-752. ISSN 0028-0836

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Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%. We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. Here we show, using two analytic approaches, the extent to which common genetic variation underlies the risk of schizophrenia. First, we implicate the major histocompatibility complex. Second, we provide molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia involving thousands of common alleles of very small effect. We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases.