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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

Purcell, Shaun M and Wray, Naomi R and Stone, Jennifer L and Visscher, Peter M and O'Donovan, Michael C and Sullivan, Patrick F and Sklar, Pamela and , International Schizophrenia Consortium and Pickard, Ben (2009) Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature, 460 (7256). pp. 748-752. ISSN 0028-0836

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Abstract

Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%. We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. Here we show, using two analytic approaches, the extent to which common genetic variation underlies the risk of schizophrenia. First, we implicate the major histocompatibility complex. Second, we provide molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia involving thousands of common alleles of very small effect. We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases.

Item type: Article
ID code: 25908
Keywords: alleles, bipolar disorder, case-control studies, Europe, female, gene frequency, genetic predisposition to disease, genetic variation, genome, human, genome-wide association study, humans, major histocompatibility Complex, male , models, genetic, multifactorial inheritance, polymorphism, single nucleotide, schizophrenia, Pharmacy and materia medica, General
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 04 Oct 2010 14:46
    Last modified: 01 Oct 2014 16:18
    URI: http://strathprints.strath.ac.uk/id/eprint/25908

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