Picture of virus under microscope

Research under the microscope...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

Explore SIPBS research

Dissolution kinetics of crystalline alpha-glucose in 2-methyl 2-butanol

Flores, M.V. and Engasser, J.M. and Halling, P.J. (2005) Dissolution kinetics of crystalline alpha-glucose in 2-methyl 2-butanol. Biochemical Engineering Journal, 22 (3). pp. 245-252. ISSN 1369-703X

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

The purpose of the present study is the development of a kinetic model to predict and understand the dissolution of crystalline alpha-glucose in 2-methyl 2-butanol. The model takes into account three processes that might control the dissolution rate of alpha-glucose crystals. The first step, the detachment of alpha-glucose molecules from the solid surface at the solid-liquid interface, is characterised by k(R), the time-independent rate constant for interfacial reaction. The second step, the mass transport of alpha-glucose from the solid-liquid interface to the bulk solution across the boundary layer, is characterised by k(T)(L(t)), the rate constant for transport which depends on the particle size, L(t), and hence on time. The third step is the mutarotation of alpha-glucose in solution, characterised by the forward mutarotation kinetic constant, k(1). The constants k(R) and k(1), are obtained by fitting the model to the experimental data of alpha- and beta-glucose concentration in the bulk as a function of time. k(T)(L(t)) is estimated using correlations based on geometry, operational conditions and alpha-glucose particle size. The particle size distribution of the primary solid particles was experimentally determined. The model fits well the experimental results, and reveals that, for stirring speeds between 300 and 700 rpm, both transport and interfacial reaction share the control of the dissolution rate of alpha-glucose in 2-methyl 2-butanol.