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World class computing and information science research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.


Operational stability of subtilisin CLECs in organic solvents in repeated batch and in continuous operation

Fernandes, J.F.A. and McAlpine, M. and Halling, P.J. (2005) Operational stability of subtilisin CLECs in organic solvents in repeated batch and in continuous operation. Biochemical Engineering Journal, 24 (1). pp. 11-15. ISSN 1369-703X

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The operational stability of cross-linked crystals (CLECs) of subtilisin Carlsberg in organic media is compared between repeated batch and continuous flow operation. The study was designed to create similar conditions in the two modes, although these can never be identical in all respects. The biocatalyst inactivates rapidly during the first two batches of 2 h each, losing 50% or more of its activity. The inactivation becomes slower over the following longer batches of 24 h. This pattern of rapid and slower phases of inactivation is similar to that observed in continuous reactors. However, in both acetonitrile and tetrahydrofuran, inactivation is somewhat faster over the first 4h of continuous operation than in the equivalent batch mode.