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World class computing and information science research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.

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Neuropsychological functioning in depressed adolescent girls

Matthews, Keith M. and Coghill, David and Rhodes, Sinéad (2008) Neuropsychological functioning in depressed adolescent girls. Journal of Affective Disorders, 111 (1). pp. 113-118. ISSN 0165-0327

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Abstract

Background: Neuropsychological impairment has been demonstrated in adults with depression. Whether depression arising during adolescence is associated with similar changes is unknown, We describe the neuropsychological functioning of a referred sample of medication-naive adolescent girls meeting criteria for a diagnosis of Depressive Episode (ICD-10). Methods: A cross-sectional study of 28 girls (ages 12-16); 14 with depression, 14 healthy controls matched for age, IQ and socioeconornic status. Neuropsychological testing was conducted using the CANTAB automated test battery. Results: Depressed adolescent girls showed performance deficits on visual memory tasks (Pattern Recognition, Delayed Matching to Sample and Paired Associates Learning), one measure of motor speed and on a test of Spatial Working Memory. Limitations: A restricted range of neuropsychological testing was performed on a female-only sample of modest size. Conclusions: Depressive episodes in adolescent girls are associated with neurocognitive deficits similar to those previously defined in adult populations and these impairments can be detected prior to exposure to psychotropic drugs. Neuropsychological impairment may be an important, neglected clinical feature in adolescent depression.