Picture of a sphere with binary code

Making Strathclyde research discoverable to the world...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. It exposes Strathclyde's world leading Open Access research to many of the world's leading resource discovery tools, and from there onto the screens of researchers around the world.

Explore Strathclyde Open Access research content

Serum profile of isosorbide mononitrate after vaginal administration in the third trimester

Bates, C.D. and Nicoll, A.E. and Mullen, A.B. and Mackenzie, F. and Thomson, A.J. and Norman, J.E. (2003) Serum profile of isosorbide mononitrate after vaginal administration in the third trimester. BJOG: An International Journal of Obstetrics and Gynaecology, 110 (1). pp. 64-67. ISSN 1470-0328

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Vaginally administered nitric oxide donors such as isosorbide mononitrate have been used to ripen the uterine cervix in pregnancy. The pharmacokinetics of isosorbide mononitrate following vaginal administration are unknown. Serum levels of isosorbide mononitrate were determined at baseline and 60, 180 and 360 minutes after vaginal administration of 20 or 40 mg isosorbide mononitrate to pregnant women scheduled for induction of labour at term. Serum levels of isosorbide mononitrate continued to rise up to 360 minutes after isosorbide mononitrate insertion, with mean (SD) final levels of 337 (94) g/L following isosorbide mononitrate 40 mg and 144 (47) g/L following isosorbide mononitrate 20 mg, P < 0.01 .