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Serum profile of isosorbide mononitrate after vaginal administration in the third trimester

Bates, C.D. and Nicoll, A.E. and Mullen, A.B. and Mackenzie, F. and Thomson, A.J. and Norman, J.E. (2003) Serum profile of isosorbide mononitrate after vaginal administration in the third trimester. BJOG: An International Journal of Obstetrics and Gynaecology, 110 (1). pp. 64-67. ISSN 1470-0328

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Abstract

Vaginally administered nitric oxide donors such as isosorbide mononitrate have been used to ripen the uterine cervix in pregnancy. The pharmacokinetics of isosorbide mononitrate following vaginal administration are unknown. Serum levels of isosorbide mononitrate were determined at baseline and 60, 180 and 360 minutes after vaginal administration of 20 or 40 mg isosorbide mononitrate to pregnant women scheduled for induction of labour at term. Serum levels of isosorbide mononitrate continued to rise up to 360 minutes after isosorbide mononitrate insertion, with mean (SD) final levels of 337 (94) g/L following isosorbide mononitrate 40 mg and 144 (47) g/L following isosorbide mononitrate 20 mg, P < 0.01 .

Item type: Article
ID code: 23178
Notes: contact email not found
Keywords: obstetrics, gynaecology, isosorbide mononitrate, Gynecology and obstetrics, Pharmacy and materia medica
Subjects: Medicine > Gynecology and obstetrics
Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Pharmaceutical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Strathprints Administrator
Date Deposited: 08 Jul 2010 09:48
Last modified: 04 Oct 2012 13:18
URI: http://strathprints.strath.ac.uk/id/eprint/23178

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