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Cytotoxic diterpenes from scoparia dulcis

Ahsan, M. and Islam, S.N. and Gray, A.I. and Stimson, W.H. (2003) Cytotoxic diterpenes from scoparia dulcis. Journal of Natural Products, 66 (7). pp. 958-961. ISSN 0163-3864

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Abstract

Four new labdane-derived diterpenes, iso-dulcinol (1), 4-epi-scopadulcic acid B (2), dulcidiol (4), and scopanolal (5), together with two known diterpenes, dulcinol/scopadulciol (3) and scopadiol (6), were isolated from the aerial parts of Scoparia dulcis. The structures were determined by extensive NMR studies. The crude extracts as well as the pure diterpenes showed cytotoxicity against a panel of six human stomach cancer cell lines.

Item type: Article
ID code: 22868
Keywords: beta-glucuronidase inhibitor, cell-lines, acid-a, triterpenoids, Pharmacy and materia medica, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Strathprints Administrator
Date Deposited: 07 Jul 2010 10:52
Last modified: 05 Sep 2014 03:40
URI: http://strathprints.strath.ac.uk/id/eprint/22868

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