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Open Access research that challenges the mind...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62

McInnes, I.B. and Gracie, J.A. and Leung, B.P. and Harnett, M.M. and Liew, F.Y. and Harnett, W. (2003) A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62. Arthritis Research and Therapy, 5 (Suppl ). p. 52. ISSN 1478-6354

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Abstract

Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.