Picture of athlete cycling

Open Access research with a real impact on health...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

Explore open research content by Physical Activity for Health...

A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62

McInnes, I.B. and Gracie, J.A. and Leung, B.P. and Harnett, M.M. and Liew, F.Y. and Harnett, W. (2003) A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62. Arthritis Research and Therapy, 5 (Suppl ). p. 52. ISSN 1478-6354

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.