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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.

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Dynamics of cardiac intracellular ca2+ handling: from experiments to virtual cells

Zhang, H. and Noble, D. and Cannell, M. and Orchard, C.H. and Lancaster, M. and Jones, S.A. and Boyett, M.R. and Holden, A.V. and Dempster, J. (2003) Dynamics of cardiac intracellular ca2+ handling: from experiments to virtual cells. International Journal of Bifurcation and Chaos, 13 (12). pp. 3535-3560. ISSN 0218-1274

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Abstract

Intracellular cardiac Ca2+ handling involves interactions of numerous distinct cellular and macromolecular structures. Such interactions coordinate the complicated behaviors of individual processes into spatial and temporal coherent patterns of Ca2+ sparks, oscillations and traveling waves. Understanding the dynamical behaviors and functional roles of intracellular Ca2+ handling requires not only detailed experimental information about subcellular structures and dynamics, but also useful tools to integrate and analyze this information. This requires interactions between experimental and simulation results within a virtual cell.