Picture of a sphere with binary code

Making Strathclyde research discoverable to the world...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. It exposes Strathclyde's world leading Open Access research to many of the world's leading resource discovery tools, and from there onto the screens of researchers around the world.

Explore Strathclyde Open Access research content

Approaching ambient temperatures in 1,2-dce to deliver efficient intermolecular dotz benzannulation processes

Irvine, S. and Kerr, W.J. and McPherson, A.R. and Pearson, C.M. (2008) Approaching ambient temperatures in 1,2-dce to deliver efficient intermolecular dotz benzannulation processes. Tetrahedron, 64 (5). pp. 926-935. ISSN 0040-4020

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Conditions have been developed that enable intermolecular Dötz benzannulations to be carried out under extremely mild conditions, using 1,2-DCE as the reaction solvent and without the requirement for any additional reaction promoters. The new protocols, at temperatures close to ambient, have been applied successfully to a range of internal and terminal alkynes with a series of aryl and alkenyl carbene complexes, resulting in good to high yields of the benzannulation products. The developed conditions did, however, return lower benzannulation yields when utilised with the traditionally more troublesome 2-furyl carbene complex. It was found that increased reaction temperatures in 1,2-DCE did deliver high yields for the processes with this heteroaryl species.