Watt, Jonathan and Wadsworth, R.M. and Kennedy, S. and Oldroyd, Keith G. (2008) Pro-healing drug-eluting stents: a role for antioxidants? Clinical Science, 114 (3-4). pp. 265-273. ISSN 0143-5221Full text not available in this repository. (Request a copy from the Strathclyde author)
Current strategies to lower the incidence of ISR (in-stent restenosis) following PCI (percutaneous coronary intervention) are aimed at modifying arterial healing after stent injury. This can impair endothelial recovery and render the vessel prone to acute thrombosis. As early restoration of endothelial integrity inhibits neointimal growth and thrombosis, alternative approaches which encourage this process may provide a more effective long-term result after PCI. Oxidative stress is enhanced after PCI and participates in the regulation of endothelial regeneration and neointimal growth. Moreover, evidence suggests antioxidants improve re-endothelialization and inhibit ISR. By promoting, rather than blocking, the healing process, antioxidant and other therapies may offer an alternative or additional approach over the antiproliferative approaches common to many current devices.
|Keywords:||antioxidant, drug-eluting stent, oxidative stress, re-endothelialization, restenosis, stent thrombosis, Pharmacy and materia medica|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Strathprints Administrator|
|Date Deposited:||04 Jun 2010 14:04|
|Last modified:||06 Jan 2017 07:37|