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Inhibition of high Mr and low Mr thioredoxin reductases from Plasmodium falciparum and Trichomonas vaginalis by organotellurides

McMillan, P.J. and Young, S.E. and Patzewitz, E.M. and Westrop, G.D. and Coombs, G.H. and Engman, L. and Muller, S. (2008) Inhibition of high Mr and low Mr thioredoxin reductases from Plasmodium falciparum and Trichomonas vaginalis by organotellurides. International Journal for Parasitology, 38. S65-S65. ISSN 0020-7519

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Abstract

Poster presented at MAM 2008, the 3rd Molecular Approaches to Malaria Meeting. The Trichomonas vaginalis TrxR was analysed to assess the efficacy of the organotellurides against a low Mr TrxR, which act by a very different mechanism to that of the high Mr TrxR. The results that will be presented show that: (a) Selectivity of inhibition between hTrxR and PfTrxR is possible (b) Selective inhibition between high Mr and low Mr TrxR can be achieved (c) The generation of inhibitors that specifically affect parasite viability is feasible.