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Inhibition of high Mr and low Mr thioredoxin reductases from Plasmodium falciparum and Trichomonas vaginalis by organotellurides

McMillan, P.J. and Young, S.E. and Patzewitz, E.M. and Westrop, G.D. and Coombs, G.H. and Engman, L. and Muller, S. (2008) Inhibition of high Mr and low Mr thioredoxin reductases from Plasmodium falciparum and Trichomonas vaginalis by organotellurides. International Journal for Parasitology, 38. S65-S65. ISSN 0020-7519

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Abstract

Poster presented at MAM 2008, the 3rd Molecular Approaches to Malaria Meeting. The Trichomonas vaginalis TrxR was analysed to assess the efficacy of the organotellurides against a low Mr TrxR, which act by a very different mechanism to that of the high Mr TrxR. The results that will be presented show that: (a) Selectivity of inhibition between hTrxR and PfTrxR is possible (b) Selective inhibition between high Mr and low Mr TrxR can be achieved (c) The generation of inhibitors that specifically affect parasite viability is feasible.

Item type: Article
ID code: 19778
Keywords: thioredoxin reductase, TrxR, Plasmodium falciparum, Trichomonas vaginalis, Pharmacy and materia medica, Microbiology, Infectious Diseases, Parasitology
Subjects: Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 03 Jun 2010 18:06
    Last modified: 05 Sep 2014 02:04
    URI: http://strathprints.strath.ac.uk/id/eprint/19778

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