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The roles of pathogen-associated molecular patterns in atherosclerosis

Erridge, C. (2008) The roles of pathogen-associated molecular patterns in atherosclerosis. Trends in Cardiovascular Medicine, 18 (2). pp. 52-56. ISSN 1050-1738

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Abstract

Stimulation of Toll-like receptors, which serve to initiate inflammatory signaling in response to the detection of conserved microbial pathogenassociated molecular patterns (PAMPs), has been shown to play a central role in the development of atherosclerosis. In this review, the recent evidence supporting a role for both infection- and commensal-derived PAMPs in the pathogenesis of atherosclerosis will be discussed. Potential sources of PAMPs, their routes of delivery to the artery wall and the mechanisms by which PAMPs may affect vascular function independently of bacteremia or infection of the artery wall with viable organisms will be examined. Finally, the recent evidence that obesity and high-fat diets may each promote translocation of commensal-derived endotoxin from the gut into the circulation to induce inflammation, insulin resistance and atherosclerosis will be discussed.

Item type: Article
ID code: 19748
Keywords: atherosclerosis, pathogen-associated molecular patterns, PAMPs, vascular function, obesity, Pathology
Subjects: Medicine > Pathology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 27 May 2010 19:33
    Last modified: 17 Jul 2013 00:25
    URI: http://strathprints.strath.ac.uk/id/eprint/19748

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