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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Sensing change in batch reactors

Ashe, R. and Littlejohn, D. and Nordon, A. and Allan, P. (2008) Sensing change in batch reactors. Chemical Engineering, 115 (3). pp. 56-59. ISSN 0009-2460

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Abstract

The batch reactor is the workhorse of the fine chemical and pharmaceutical industries. This article discusses a relatively straightforward design change, constant flux control, which delivers compelling benefits to both temperature control and process monitoring. One of the most intractable problems of scale up is that of temperature control. The function of reactor jackets is to add or remove heat. Where this heat can be measured, however, it can also serve as a valuable process analytical technology tool. Constant flux control affects the mechanical design of the external cooling jacket and temperature control valve. With this design, temperature control is not only faster and more stable, but the problem of hot and cold spots in the jacket is also eliminated.