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Par-2 in the pathogenesis of collagen-induced arthritis: crucial role in T cell differentiation

Nickdel, M.B. and Palmer, H.S. and Ferrell, W.R. and Lockhart, J.C. and Plevin, R.J. and McInnes, I.B. (2008) Par-2 in the pathogenesis of collagen-induced arthritis: crucial role in T cell differentiation. Rheumatology, 47 (Supplement 2). II54-II54. ISSN 1462-0324

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Abstract

Protease-activated receptor-2 (PAR-2) is a member of a novel family of seven-transmembrane G-protein-coupled receptors (PARs) activated by proteolytic cleavage to reveal a tethered ligand. Serine proteases such as mast cell tryptase cleave PAR-2 at a specific site within the extracellular N-terminus to expose a new N-terminal tethered ligand domain, which binds to and thereby activates the cleaved receptor. We previously demonstrated that adjuvant monoarthritis is substantially inhibited in PAR-2 'knockout' mice (1). The present study extended these earlier finding by investigating the therapeutic potential of a novel PAR-2 antagonist, ENMD-1068, in the murine model of collagen-induced arthritis (CIA); we recently demonstrated this antagonist inhibited TNF generation from the synovial membrane of RA patients (2). We further tested the hypothesis that this receptor contributes to the pathogenesis of arthritis by affecting T lymphocyte activation and/or differentiation to Th1, Th2 and Th17 phenotypes.

Item type: Article
ID code: 19697
Keywords: collagen-induced arthritis, t cell differentiation, arthritis, Pharmacy and materia medica
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Centre for Biophotonics
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 04 Jun 2010 16:26
    Last modified: 06 Dec 2013 22:03
    URI: http://strathprints.strath.ac.uk/id/eprint/19697

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