Strathprints logo
Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men

Gray, S.R. and Robinson, M. and Nimmo, M.A. (2008) Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men. Cell Stress and Chaperones, 13 (2). pp. 247-251. ISSN 1355-8145

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

The pleiotropic cytokine interleukin-6 (IL-6) has been demonstrated to increase during exercise. Little is known regarding the response of the soluble IL-6 receptors (sIL-6R and sgp130) during such exercise. The aim of the current study was to investigate the response of plasma IL-6, sIL-6R and sgp130 during fatiguing submaximal exercise in humans. Twelve participants underwent an incremental exercise test to exhaustion and one week later performed a submaximal exercise bout (96 ± 6% lactate threshold) to volitional exhaustion. Blood samples taken at rest and immediately post exercise were analyzed for IL-6, sIL-6R and sgp130. IL-6 increased (P < 0.01) by 8.4 ± 8.9 pg ml−1 (75.7%) during the exercise period. sIL-6R and sgp130 also increased (P < 0.05) by 2.7 ± 3.9 ng ml−1 (9.6%) and 37.7 ± 55.6 ng ml−1 (9.6%), respectively. The current study is the first investigation to demonstrate that alongside IL-6, acute exercise stress results in an increase in both sIL-6R and sgp130.

Item type: Article
ID code: 19682
Keywords: exercise stress, interleukin-6, receptors, fatigue, Sports Medicine, Pharmacy and materia medica, Biochemistry, Cell Biology
Subjects: Medicine > Internal medicine > Sports Medicine
Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 07 Jun 2010 10:04
    Last modified: 05 Sep 2014 02:22
    URI: http://strathprints.strath.ac.uk/id/eprint/19682

    Actions (login required)

    View Item