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World class computing and information science research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.

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Endothelial cell response to narrow diameter nylon tubes exhibiting internal nanotopography

Berry, C. and McCloy, D. and Affrossman, S. (2008) Endothelial cell response to narrow diameter nylon tubes exhibiting internal nanotopography. Current Nanoscience, 4 (2). pp. 219-223. ISSN 1573-4137

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Abstract

The use of three dimensional scaffolds in tissue engineering is well reported, as is the exploitation of nanotopography to influence cell response. To date, due to fabrication limitations, the combination of these two has experienced limited research. This paper reports on the use of polymer demixing, a rapid and cheap nanofabrication method, to create a defined nanotopography in 0.5mm diameter nylon tubes. Results indicate that the resultant nano-island topography reduced endothelial cell adhesion and spreading, strongly influenced cell morphology, and appeared to increase endocytic activity. The use of such constructs that boast topographical cues have great potential in tissue and cell engineering studies for future clinical use, in particular with respect to conduits and stents.