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Endothelial cell response to narrow diameter nylon tubes exhibiting internal nanotopography

Berry, C. and McCloy, D. and Affrossman, S. (2008) Endothelial cell response to narrow diameter nylon tubes exhibiting internal nanotopography. Current Nanoscience, 4 (2). pp. 219-223. ISSN 1573-4137

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Abstract

The use of three dimensional scaffolds in tissue engineering is well reported, as is the exploitation of nanotopography to influence cell response. To date, due to fabrication limitations, the combination of these two has experienced limited research. This paper reports on the use of polymer demixing, a rapid and cheap nanofabrication method, to create a defined nanotopography in 0.5mm diameter nylon tubes. Results indicate that the resultant nano-island topography reduced endothelial cell adhesion and spreading, strongly influenced cell morphology, and appeared to increase endocytic activity. The use of such constructs that boast topographical cues have great potential in tissue and cell engineering studies for future clinical use, in particular with respect to conduits and stents.

Item type: Article
ID code: 19680
Keywords: fibrblast response, poly(lactic-co-glycolic acid), colloidal lithography, surface features, nano topography, blends, polystyrene, constructs, microscale, morphology, Chemistry, Biomedical Engineering, Bioengineering, Pharmaceutical Science, Biotechnology, Medicine (miscellaneous)
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 07 Jun 2010 11:38
    Last modified: 05 Sep 2014 02:17
    URI: http://strathprints.strath.ac.uk/id/eprint/19680

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