Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Engineering silica particles as oral drug delivery vehicles

Rigby, S.P. and Fairhead, M. and van der Walle, Christopher F. (2008) Engineering silica particles as oral drug delivery vehicles. Current Pharmaceutical Design, 14 (18). pp. 1821-1831. ISSN 1381-6128

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Porous silica particles are emerging as complementary systems to polyester microspheres for the encapsulation and controlled delivery of small-organic drugs. Their recent application in pharmaceutics is strengthened by well-established characterization and synthetic routes from the chemical engineering sciences. Silica is an interesting scaffold material for the encapsulation of organic molecules. It can be formed into hierarchical structures over a wide range of length scales and interconnectivities. Encapsulation can therefore be tailored not only to the drug but the desired release properties. In addition to surfactant-templating of hierarchical silica structures, polypeptides from marine organisms may offer biological routes to novel silica materials. Silica sol-gels have also been evaluated as delivery vehicles, particularly with regard to generating hybrid systems with mesoporous silica or composite xerogels. This review will first focus on the detailed characterisation of pore size and structure of mesoporous silica with regards water penetration and drug diffusion. We then describe the pharmaceutical applications of silica materials with regard to improving oral bioavailability, multiparticulate systems for gastroretention or sustained release, composite xerogels and in vivo biocompatibility.

Item type: Article
ID code: 19609
Keywords: mesoporous silica, pore size, xerogels, dissolution, drug release, passive targeting, biosilica, Therapeutics. Pharmacology
Subjects: Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 19 May 2010 18:08
    Last modified: 17 Jul 2013 00:33
    URI: http://strathprints.strath.ac.uk/id/eprint/19609

    Actions (login required)

    View Item