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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Ca2+-signalling pathways involved in P2X receptor-induced contractions of rat small pulmonary artery

Kennedy, Charles and Syed, Nawazish-i-Husain (2008) Ca2+-signalling pathways involved in P2X receptor-induced contractions of rat small pulmonary artery. Purinergic Signalling, 4 (S1). S201-S201. ISSN 1573-9538

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Abstract

P2X receptors are Ca2+-permeable, ligand-gated cation channels, which are activated by ATP. In arteries, including the rat small pulmonary artery (SPA), they elicit vasoconstriction (Chootip et al., 2002), which is dependent upon extracellular Ca2+. The aim of this study was to determine the relative contributions of Ca2+ influx via the P2X receptor pore and voltage-dependent CaV1.2 (L-type) Ca2+ channels, and the role of Ca2+-induced Ca2+ release (CICR) in P2X receptormediated contractions of rat SPA.