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Ca2+-signalling pathways involved in P2X receptor-induced contractions of rat small pulmonary artery

Kennedy, Charles and Syed, Nawazish-i-Husain (2008) Ca2+-signalling pathways involved in P2X receptor-induced contractions of rat small pulmonary artery. Purinergic Signalling, 4 (S1). S201-S201. ISSN 1573-9538

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Abstract

P2X receptors are Ca2+-permeable, ligand-gated cation channels, which are activated by ATP. In arteries, including the rat small pulmonary artery (SPA), they elicit vasoconstriction (Chootip et al., 2002), which is dependent upon extracellular Ca2+. The aim of this study was to determine the relative contributions of Ca2+ influx via the P2X receptor pore and voltage-dependent CaV1.2 (L-type) Ca2+ channels, and the role of Ca2+-induced Ca2+ release (CICR) in P2X receptormediated contractions of rat SPA.