Picture of Open Access badges

Discover Open Access research at Strathprints

It's International Open Access Week, 24-30 October 2016. This year's theme is "Open in Action" and is all about taking meaningful steps towards opening up research and scholarship. The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Explore recent world leading Open Access research content by University of Strathclyde researchers and see how Strathclyde researchers are committing to putting "Open in Action".


Image: h_pampel, CC-BY

One-pot reduction of aryl iodides using 4-dmap methiodide salt

Garnier, J. and Murphy, J.A. and Zhou, S.Z. and Turner, A.T. and , EPRSC (Funder) and , University of Strathclyde (Funder) and , AstraZeneca (Funder) (2008) One-pot reduction of aryl iodides using 4-dmap methiodide salt. Synlett (14). pp. 2127-2131. ISSN 0936-5214

Full text not available in this repository. (Request a copy from the Strathclyde author)


An efficient one-pot procedure is described for the reduction of aryl iodides to aryl anions using a structurally simple bis-pyridinylidene electron donor, prepared in situ by treating 4-DMAP methiodide salt with base. The results show (i) that pyridinylidene carbenes can be easily used for intermolecular C-C bond formation, (ii) that bis-pyridinylidenes demonstrate superior robustness compared to electron-donor systems based on bis-imidazolylidenes, and (iii) that electron-donor strength is enhanced in the simplified DMAP-based donor. Deuterated analogues of this donor also provide mechanistic information on the source of protons when the aryl anions are quenched in situ.