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A hybrid three-dimensional nanofabrication method for producing vascular tissue engineering scaffold

Gadegaard, N. and Seunarine, K. and Smith, David J.A. and Meredith, D.O. and Wilkinson, C.D.W. and Riehle, M.O. (2008) A hybrid three-dimensional nanofabrication method for producing vascular tissue engineering scaffold. Journal of Applied Physics, 47 (9). pp. 7415-7419. ISSN 0021-8979

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There is a trend towards the production of lithographically defined materials for biological applications. The field of nanobio technology is rapidly growing and so is demand for materials nanostructured in three dimensions. Here we present a hybrid approach where where we use electron beam lithography, photolithography and hot embossing to produce membranes patterned on both sides. The double sided patterned membranes were subsequently rolled to create the three dimensional tissue construct aimed at vascular repair. The mechanical properties such as bending and bursting pressure were also investigated.