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Natural products in drug discovery

Harvey, Alan L (2008) Natural products in drug discovery. Drug Discovery Today, 13 (19-20). pp. 894-901. ISSN 1359-6446

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Abstract

Natural products have been the single most productive source of leads for the development of drugs. Over a 100 new products are in clinical development, particularly as anti-cancer agents and anti-infectives. Application of molecular biological techniques is increasing the availability of novel compounds that can be conveniently produced in bacteria or yeasts, and combinatorial chemistry approaches are being based on natural product scaffolds to create screening libraries that closely resemble drug-like compounds. Various screening approaches are being developed to improve the ease with which natural products can be used in drug discovery campaigns, and data mining and virtual screening techniques are also being applied to databases of natural products. It is hoped that the more efficient and effective application of natural products will improve the drug discovery process.

Item type: Article
ID code: 19466
Keywords: animal compounds, biological products, computer simulation, drug design, drug evaluation, preclinical, humans, pharmacology, plant compounds, Pharmacy and materia medica
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Strathprints Administrator
Date Deposited: 08 Jun 2010 14:54
Last modified: 19 Sep 2013 11:51
URI: http://strathprints.strath.ac.uk/id/eprint/19466

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