Harvey, Alan L (2008) Natural products in drug discovery. Drug Discovery Today, 13 (19-20). pp. 894-901. ISSN 1359-6446Full text not available in this repository. (Request a copy from the Strathclyde author)
Natural products have been the single most productive source of leads for the development of drugs. Over a 100 new products are in clinical development, particularly as anti-cancer agents and anti-infectives. Application of molecular biological techniques is increasing the availability of novel compounds that can be conveniently produced in bacteria or yeasts, and combinatorial chemistry approaches are being based on natural product scaffolds to create screening libraries that closely resemble drug-like compounds. Various screening approaches are being developed to improve the ease with which natural products can be used in drug discovery campaigns, and data mining and virtual screening techniques are also being applied to databases of natural products. It is hoped that the more efficient and effective application of natural products will improve the drug discovery process.
|Keywords:||animal compounds, biological products, computer simulation, drug design, drug evaluation, preclinical, humans, pharmacology, plant compounds, Pharmacy and materia medica, Pharmaceutical Science|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Strathprints Administrator|
|Date Deposited:||08 Jun 2010 13:54|
|Last modified:||27 Apr 2016 14:55|