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Thermal investigation into the interaction of cetostearyl alcohol and a cetostearyl alcohol/sodium lauryl sulphate mixed emulsifier with liquid paraffin

Rouse, J.J. and Kim, J.H. and Lawrence, M.J. and Eccleston, G.M. (2008) Thermal investigation into the interaction of cetostearyl alcohol and a cetostearyl alcohol/sodium lauryl sulphate mixed emulsifier with liquid paraffin. Journal of Pharmacy and Pharmacology, 60 (S1). A61-A61. ISSN 0022-3573

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Abstract

In previous work, mobile nanoemulsions were prepared by the ultrasonication of liquid paraffin (LP) in water macroemulsions containing the mixed emulsifier (ME) sodium lauryl sulphate (SLS) and cetostearyl alcohol (CSA; Kim et al 2007). It was shown that the lamellar gel networks, formed when the ME interacts with water (ternary system), were not present in freshly prepared nanoemulsions. In these systems, the endotherm associated with the lamellar phase was absent and replaced by a prominent, broad unidentified endotherm between 50 and 60C. The aim of this work was to identify the nature of this endotherm to gain a better understanding of nanoemulsion microstructure. To this end, the interactions of the ME and its components in oil were investigated.