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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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The interplay between human b cells, eosinophils and helminths: a novel aspect of the hygiene hypothesis

Mammen, A. and Farraye, F.A. and Liang, Y. and Harnett, W. and Shin, H. and Harnett, M.M. and Nikolajczyk, B. and Ganley-Leal, L. (2008) The interplay between human b cells, eosinophils and helminths: a novel aspect of the hygiene hypothesis. American Journal of Tropical Medicine and Hygiene, 79 (6). pp. 337-338. ISSN 0002-9637

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Abstract

The hygiene hypothesis is based on the premise that lack of exposure to helminths predisposes certain individuals to immune-mediated disease, such as inflammatory bowel disease (IBD). This hypothesis is supported by epidemiological data that shows developed countries with a low prevalence of helminth infections have higher incidence of allergic and inflammatory diseases. Helminths modulate the host immune response in a manner that dampens the exaggerated response to innocuous antigens, such as commensal bacteria.