Mammen, A. and Farraye, F.A. and Liang, Y. and Harnett, W. and Shin, H. and Harnett, M.M. and Nikolajczyk, B. and Ganley-Leal, L. (2008) The interplay between human b cells, eosinophils and helminths: a novel aspect of the hygiene hypothesis. American Journal of Tropical Medicine and Hygiene, 79 (6). pp. 337-338. ISSN 0002-9637Full text not available in this repository. (Request a copy from the Strathclyde author)
The hygiene hypothesis is based on the premise that lack of exposure to helminths predisposes certain individuals to immune-mediated disease, such as inflammatory bowel disease (IBD). This hypothesis is supported by epidemiological data that shows developed countries with a low prevalence of helminth infections have higher incidence of allergic and inflammatory diseases. Helminths modulate the host immune response in a manner that dampens the exaggerated response to innocuous antigens, such as commensal bacteria.
|Keywords:||human b cells, eosinophils, helminth, hygiene hypothesis, immune-mediated disease, inflammatory bowel disease, Immunology, Infectious Diseases, Virology, Parasitology|
|Subjects:||Science > Microbiology > Immunology|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Strathprints Administrator|
|Date Deposited:||02 Jun 2010 09:13|
|Last modified:||29 Apr 2016 01:00|