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Analysis of E3 ubiquitin-protein ligases in antigen-specific CD4(+) T cells during tolerance and priming

Bicheiro, L. and Morton, A.M. and Garside, P. and Mowat, A.M. and Harnett, M.M. (2008) Analysis of E3 ubiquitin-protein ligases in antigen-specific CD4(+) T cells during tolerance and priming. Immunology, 125 (s1). p. 128. ISSN 0019-2805

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Abstract

Peripheral tolerance plays an important role in preventing T lymphocyte responses to self or harmless antigens. One of the mechanisms that contributes to this form of tolerance is anergy, which is characterized by a lack of proliferation and IL-2 production by T cells in response to antigenic challenge. The acquisition of the anergic phenotype is an active process, with negative regulators of T cell signaling being induced. Among these are the E3 ubiquitin-protein ligases which recognize target proteins for ubiquitination and catalyze the transfer of ubiquitin to them, directing them to the proteasome or to the endosome-lysosomal pathway, and hence down-regulating their activity.

Item type: Article
ID code: 19306
Keywords: E3 ubiquitin-protein ligases, antigen-specific, CD4(+) t cells, immunology, Immunology, Pharmacy and materia medica, Immunology, Immunology and Allergy
Subjects: Science > Microbiology > Immunology
Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 18 May 2010 16:13
    Last modified: 05 Sep 2014 02:48
    URI: http://strathprints.strath.ac.uk/id/eprint/19306

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