Mokgethi, T. and Nickdel, M.B. and Henriquez, F.L. and Roberts, F. and Brombacher, F. and Roberts, Craig and Alexander, J. (2008) The role of IL-4R alpha signalling during toxoplasma gondii infection. Immunology, 125 (s1). p. 110. ISSN 0019-2805
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
The protective immune response against Toxoplasma gondii is widely recognised as being type-1 mediated. Nevertheless, the overproduction of type-1 cytokines can induce severe pathology. The extent to which Th2 cytokines can modulate the disease protective versus disease exacerbating effects of type-1 cytokines remains to be resolved. We have therefore, compared the disease induced by T. gondii cysts in IL-4)/), IL-4Ra)/), and wild-type BALB/c mice, a mouse strain normally resistant to this disease. Increased mortality and increased lung pathology were observed in the absence of IL-4 and signalling via IL-4Ra and splenocyte type 1 cytokine and NO production was increased during early infection (day 12). IL-4 can modulate type-1 inflammatory responses by counter-regulating the effects of IFN-c on CD4+ T cells and/or macrophages.
| Item type: | Article |
|---|---|
| ID code: | 19304 |
| Keywords: | IL-4R alpha signalling, toxoplasma gondii infection, Immunology, Biology, Pharmacy and materia medica |
| Subjects: | Science > Microbiology > Immunology Science > Natural history > Biology Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Science > Centre for Biophotonics Faculty of Science > Immunology Faculty of Science > Mathematics and Statistics |
| Related URLs: | |
| Depositing user: | Strathprints Administrator |
| Date Deposited: | 18 May 2010 15:24 |
| Last modified: | 18 Dec 2012 11:28 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/19304 |
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