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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Plasmacytoid dendritic cells and antigen presentation to CD4+t cells

Benson, R.A. and Hutchison, S. and Millington, O.R. and McInnes, I.B. and Garside, P. and Brewer, J.M. (2008) Plasmacytoid dendritic cells and antigen presentation to CD4+t cells. Immunology, 125 (s1). p. 102. ISSN 0019-2805

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Abstract

The enigmatic antigen presenting role of plasmacytoid dendritic cells (pDCs) has generated considerable interest in recent years. More recently,their interactions with CD4+ T cells and subsequent regulation of pathology in models of autoimmune disease have made them interesting targets for biological intervention. Our studies in a novel murine model of rheumatoid arthritis (RA), demonstrate that pDCs act to limit the spontaneous induction of auto-reactive T cell responses and autoantibody production and can limit the severity of pathology.