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Plasmacytoid dendritic cells and antigen presentation to CD4+t cells

Benson, R.A. and Hutchison, S. and Millington, O.R. and McInnes, I.B. and Garside, P. and Brewer, J.M. (2008) Plasmacytoid dendritic cells and antigen presentation to CD4+t cells. Immunology, 125 (s1). p. 102. ISSN 0019-2805

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Abstract

The enigmatic antigen presenting role of plasmacytoid dendritic cells (pDCs) has generated considerable interest in recent years. More recently,their interactions with CD4+ T cells and subsequent regulation of pathology in models of autoimmune disease have made them interesting targets for biological intervention. Our studies in a novel murine model of rheumatoid arthritis (RA), demonstrate that pDCs act to limit the spontaneous induction of auto-reactive T cell responses and autoantibody production and can limit the severity of pathology.

Item type: Article
ID code: 19303
Keywords: plasmacytoid dendritic cells, antigen presentation, CD4+t cells, immunology, Immunology, Pharmacy and materia medica, Biology
Subjects: Science > Microbiology > Immunology
Medicine > Pharmacy and materia medica
Science > Natural history > Biology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Centre for Biophotonics
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 18 May 2010 15:16
    Last modified: 06 Dec 2013 22:15
    URI: http://strathprints.strath.ac.uk/id/eprint/19303

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