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Analysing the role of ERK MAPK signalling and potential downstream cell cycle modulators in tolerance and priming of antigen-specific cd4(+) T-cells in vitro and in vivo

Morton, A.M. and Garside, P. and Mowat, A.M. and Harnett, M.M. (2008) Analysing the role of ERK MAPK signalling and potential downstream cell cycle modulators in tolerance and priming of antigen-specific cd4(+) T-cells in vitro and in vivo. Immunology, 125 (S1). p. 27. ISSN 0019-2805

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Abstract

T-cell recognition of Ag can result in priming or tolerance depending on the context in which Ag is recognised. We have previously shown that both qualitative and quantitative differences in T-cell signalling underlie the differential outcomes of priming and tolerance of antigenspecific T-cells.