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Open Access research that challenges the mind...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Analysing the role of ERK MAPK signalling and potential downstream cell cycle modulators in tolerance and priming of antigen-specific cd4(+) T-cells in vitro and in vivo

Morton, A.M. and Garside, P. and Mowat, A.M. and Harnett, M.M. (2008) Analysing the role of ERK MAPK signalling and potential downstream cell cycle modulators in tolerance and priming of antigen-specific cd4(+) T-cells in vitro and in vivo. Immunology, 125 (S1). p. 27. ISSN 0019-2805

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Abstract

T-cell recognition of Ag can result in priming or tolerance depending on the context in which Ag is recognised. We have previously shown that both qualitative and quantitative differences in T-cell signalling underlie the differential outcomes of priming and tolerance of antigenspecific T-cells.