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Dibromopyrrole alkaloids from the marine sponge acanthostylotella sp

Ebada, Sherif S. and Edrada-Ebel, RuAngelie and de Voogd, N.J. and Wray, V. and Proksch, Peter (2009) Dibromopyrrole alkaloids from the marine sponge acanthostylotella sp. Natural Product Communications, 4 (1). pp. 47-52. ISSN 1934-578X

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Abstract

Fourteen dibromopyrrole alkaloids were isolated from the marine sponge Acanthostylotella sp. collected in Indonesia. In addition to the known compounds 4,5-dibromo-N-(methoxy-methyl)-1H-pyrrole-2-carboxamide (7), 4,5-dibromo-1H-pyrrole-2-carboxamide (8), mukanadin D (9), (+/-)-longamide B methyl ester (10), (+/-)-longamide B (11), (+/-)-longamide (12), 3,4-dibromo-lH-pyrrole-2-carboxamide (13), 2-cyano-4,5-dibromo-1H-pyrrole (14), six compounds were isolated that proved to be new natural products including acanthamides A-D (1-4), methyl 3,4-dibromo-1H-pyrrole-2-carboxylate (5) and 3,5-dibromo-1H-pyrrole-2-carboxylic acid (6). The structures of the new compounds were unequivocally identified based on one and two dimensional NMR and on HRFTMS as well as by comparison with the literature.

Item type: Article
ID code: 19294
Notes: PMID: 19370874
Keywords: dibrominated alkaloids, acanthamide, acanthostylotella, pharmacology, Chemistry, Therapeutics. Pharmacology, Medicine(all)
Subjects: Science > Chemistry
Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Strathprints Administrator
Date Deposited: 23 Aug 2010 14:58
Last modified: 05 Sep 2014 02:57
URI: http://strathprints.strath.ac.uk/id/eprint/19294

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