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Intra-articular injection composed of steroid, iohexol and local anaesthetic - is it stable?

Shah, K. and Watson, D.G. and Campbell, C. and Meek, R.M.D. (2009) Intra-articular injection composed of steroid, iohexol and local anaesthetic - is it stable? British Journal of Radiology, 82 (974). pp. 109-111. ISSN 0007-1285

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The aim of this study is to determine the chemical stability of a suspension of steroid, radiographic contrast material and local anaesthetic. Image-guided steroid injection using a contrast material is widely used for several musculoskeletal conditions. Manufacturers of these agents do not advise mixture in a single syringe, as the chemical stability is unknown. They suggest that, if required, these agents should be injected separately. However, the agents will be mixed together when injected into a contained space within the body. it would seem unethical to continue this in clinical practice until the stability of such a mixture is established. High-performance liquid chromatographic (HPLC) analysis was used to assess the stability of combinations of steroids (triamcinolone and methylprednisolone) and Omnipaque (TM) (iohexol). Further analysis was also performed to test the stability of adding local anaesthetics (lidocaine and bupivacaine) to these mixtures. The results demonstrated that all combinations were stable when mixed together. in conclusion, these results support the continued safe use of these products in combination in clinical practice.

Item type: Article
ID code: 19275
Keywords: arthrography, shoulder, fluoroscopy, blocks, joint, hip, Pharmacy and materia medica, Radiology Nuclear Medicine and imaging
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Physics
Faculty of Humanities and Social Sciences (HaSS) > School of Psychological Science and Health > Psychology
Depositing user: Strathprints Administrator
Date Deposited: 09 Jun 2010 14:11
Last modified: 21 May 2015 12:00

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