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Cytotoxicity study of Ferula hermonis Boiss

Elouzi, A.A. and Auzi, A.A. and El-Hammadi, M. and Gray, A.I. (2008) Cytotoxicity study of Ferula hermonis Boiss. Bulletin of Pharmaceutical Sciences, 31 (2). pp. 313-317. ISSN 1110-0052

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Abstract

Ferula hermonis Boiss (Apiaceae) is known in the Midleast as 'zallouh'. In the last decade, scientists paid attention to study chemistry and biological activity of the plant. In this study Ferula hermonis were collected and evaluated for cytotoxic activity. The plant was extracted using different polarity solvents: petroleum ether, ethyl acetate and methanol. The cytotoxic effect of the extracts was examined in-vitro on human cell line (stomach cancer cell line, SCL-40). The assay was based on incubation of tetrazolium dye (MTT; a yellow water-soluble tetrazolium dye that is reduced by live, but not dead cells) with the cells that pre-incubated with a tested substance. A purple formazan product that produced can be determined spectrophotometrically. The result confirmed that the SCL-40 cells were much more sensitive to the petroleum extract than other extracts, which showed the prominent cytotoxicity. The plant showed pronounced cytotoxic activity will be further evaluated for the possible isolation of active antitumour compounds.

Item type: Article
ID code: 19135
Keywords: Ferula hermonis Boiss, Apiaceae, zallouh, chemistry, biological activity, plants, cytotoxic activity, polarity solvents, petroleum ether, ethyl acetate, methanol, Botany, Chemistry
Subjects: Science > Botany
Science > Chemistry
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Unknown Department
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 20 May 2010 18:47
    Last modified: 04 Oct 2012 13:02
    URI: http://strathprints.strath.ac.uk/id/eprint/19135

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