Dunning, L. and Lockhart, J.C. and Ferrell, W.R. and Plevin, R.J. and Gracie, J.A. and McInnes, I.B. and Boyd, G.W. (2009) Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2. Rheumatology, 48 (Supplement 1). i38-i38. ISSN 1462-0324
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
Background: Protease-activated receptor-2 (PAR-2) is one member of a family of G-protein coupled receptors which is activated by N-terminus cleavage by serine proteases to reveal a unique tethered ligand. We previously demonstrated that PAR-2 plays an important role in adjuvant arthritis as joint inflammation was substantially ablated in PAR-2 deficient mice (1). Furthermore, a monoclonal antibody to PAR-2 (SAM-11) significantly reduced acute joint inflammation (2). The object of the present study was to establish whether PAR-2 blockade using a monoclonal antibody directed to the tethered ligand sequence would be effective at inhibiting two murine models of experimental arthritis.
| Item type: | Article |
|---|---|
| ID code: | 19130 |
| Keywords: | chronic arthritis, monoclonal antibody, protease activated receptor-2, Pharmacy and materia medica |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Science > Centre for Biophotonics |
| Related URLs: | |
| Depositing user: | Strathprints Administrator |
| Date Deposited: | 20 May 2010 14:08 |
| Last modified: | 04 Oct 2012 13:10 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/19130 |
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