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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2

Dunning, L. and Lockhart, J.C. and Ferrell, W.R. and Plevin, R.J. and Gracie, J.A. and McInnes, I.B. and Boyd, G.W. (2009) Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2. Rheumatology, 48 (Supple). i38-i38. ISSN 1462-0324

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Abstract

Background: Protease-activated receptor-2 (PAR-2) is one member of a family of G-protein coupled receptors which is activated by N-terminus cleavage by serine proteases to reveal a unique tethered ligand. We previously demonstrated that PAR-2 plays an important role in adjuvant arthritis as joint inflammation was substantially ablated in PAR-2 deficient mice (1). Furthermore, a monoclonal antibody to PAR-2 (SAM-11) significantly reduced acute joint inflammation (2). The object of the present study was to establish whether PAR-2 blockade using a monoclonal antibody directed to the tethered ligand sequence would be effective at inhibiting two murine models of experimental arthritis.