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Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2

Dunning, L. and Lockhart, J.C. and Ferrell, W.R. and Plevin, R.J. and Gracie, J.A. and McInnes, I.B. and Boyd, G.W. (2009) Inhibition of murine chronic arthritis by a monoclonal antibody against protease-activated receptor-2. Rheumatology, 48 (Supple). i38-i38. ISSN 1462-0324

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Abstract

Background: Protease-activated receptor-2 (PAR-2) is one member of a family of G-protein coupled receptors which is activated by N-terminus cleavage by serine proteases to reveal a unique tethered ligand. We previously demonstrated that PAR-2 plays an important role in adjuvant arthritis as joint inflammation was substantially ablated in PAR-2 deficient mice (1). Furthermore, a monoclonal antibody to PAR-2 (SAM-11) significantly reduced acute joint inflammation (2). The object of the present study was to establish whether PAR-2 blockade using a monoclonal antibody directed to the tethered ligand sequence would be effective at inhibiting two murine models of experimental arthritis.