Shaikh, J. and Ankola, D.D. and Beniwal, V. and Singh, D. and Kumar, M.N.V. Ravi (2009) Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. European Journal of Pharmaceutical Sciences, 37 (3-4). pp. 223-230. ISSN 0928-0987Full text not available in this repository. (Request a copy from the Strathclyde author)
Curcumin, a derived product from common spice turmeric that is safe and beneficial in several aliments was formulated into biodegradable nanoparticles with a view to improve its oral bioavailability. The curcumin encapsulated nanoparticles prepared by emulsion technique were spherical in shape with particle size of 264 rim (polydispersity index 0.31) and 76.9% entrapment at 15% loading. The curcumin encapsulated nanoparticles were able to withstand the International Conference on Harmonisation (ICH) accelerated stability test conditions for refrigerated products for the studied duration of 3 months. X-ray diffraction analysis revealed the amorphous nature of the encapsulated curcumin. The in vitro release was predominantly by diffusion phenomenon and followed Higuchi's release pattern. The in vivo pharmacokinetics revealed that curcumin entrapped nanoparticles demonstrate at least 9-fold increase in oral bioavailability when compared to curcumin administered with piperine as absorption enhancer. Together the results clearly indicate the promise of nanoparticles for oral delivery of poorly bioavailable molecules like curcumin.
|Keywords:||curcumin, bioavailability, nanoparticles, oral, piperine, behavior in-vitro, plga nanoparticles, formulation, estradiol, delivery, pharmacokinetics, stability, therapy, design, vivo, Therapeutics. Pharmacology, Pharmaceutical Science|
|Subjects:||Medicine > Therapeutics. Pharmacology|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Strathprints Administrator|
|Date Deposited:||09 Jun 2010 13:08|
|Last modified:||04 May 2016 16:11|