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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

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Direct reductive aminations with catalytic molybdenum dioxide dichloride and phenylsilane

Smith, Clive A. and Cross, Laura E. and Hughes, Kimberley and Davis, Rebecca E. and Judd, Duncan B. and Merritt, Andrew T. (2009) Direct reductive aminations with catalytic molybdenum dioxide dichloride and phenylsilane. Tetrahedron Letters, 50 (34). pp. 4906-4911. ISSN 0040-4039

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Abstract

A powerful direct reductive amination (DRA) method is developed, using catalytic MoO2Cl2 and phenylsilane (PhSiH3) as the reducing agent. The alkylation of a range of amines (pK(a) 0-7.8) with both an electron-deficient and two electron-rich-aldehydes is achieved in good to excellent yields. The novel employment of this DRA in alcoholic solvents significantly improves the reaction scope and excellent functional group selectivity is exhibited.